Pioglitazone: From discovery to clinical practice Essay

The most common type of diabetes is Type II diabetes mellitus which occurs in more that 90% of the cases of diabetes reported (Thomas, 2013). Type I diabetes is not as common  and is caused by destruction of the islet of Langerhans due to susceptibility of an autoimmune destruction leading to a reduced amount of insulin produced and glucose intolerance (Feinglos,2008). Type I diabetes is mostly diagnosed in children and young adults. Unlike diabetes type  I, Type II diabetes mellitus is mostly diagnosed in older people and is caused by unhealthy lifestyles (Thomas, 2013). Type II diabetes is characterized by production of insulin which does not perform its function. It in turn leads to a situation referred to as insulin resistance. The patients will suffer from low levels of insulin which functions as   a component  for the regulation of body sugar (Feinglos, 2008). The number of islets of Langerhans in the pancreas is normal or somewhat reduced. It is mostly characterized by hyperglycemia that is associated with the insufficient or dysfunctional insulin present in the body (Thomas, 2013). Abnormal coagulation, hypertension and diabetic dyslipidemia are also commonly reported to signify the occurrence of type II diabetes mellitus. The increased number of obesity cases has seen the diagnosis of diabetes mellitus type II in teenagers and young adults (Feinglos, 2008). In cases when the patient is not obese, there is a presence of high fat distribution in the body (Feinglos, 2008). People suffering from Type II diabetes mellitus, unlike type I diabetes, do not need regular injections of insulin (Thomas, 2013). The management of type II diabetes involves the control of the increased levels of blood sugar. It is, however, important to note that the reduction of the sugar levels should not surpass the normal blood sugar levels. Because most of the patients are overweight, exercise, a proper balanced diet and reduction of weight is fundamental in the management of type II diabetes mellitus (Feinglos, 2008). Pioglitazone                  Pioglitazone is a drug belonging to a class of thiazolidinediones and is used in the management and of type II diabetes mellitus (Schatz, 2000). Since the body is unable to control the increasing levels of sugar in the blood, pioglitazone is used to increase the sensitivity to insulin (Feinglos, 2008). The drug, however, does not cure the diabetes mellitus but only helps the body in maintaining  normal  blood sugar levels. It is an oral formulation and can be taken twice daily with or without taking meals (Schatz, 2000). It is able to achieve this by inhibiting the hepatic gluconeogenesis process and also increase peripheral and splanchnic glucose uptake which implies that there is a minimal occurrence of increased blood sugar levels (Feinglos, 2008). It effects can be seen in the short term and also in the long-term (Schatz, 2000). The use of pioglitazone can be done according to the doctor’s prescription. It also important to inform the docto r before stopping the use or if any complications arise while using pioglitazone.The development of pioglitazone is based on the discovery of gene SOCS3 (Suppressor of Cytokine Signaling-3) (Schatz, 2000). The elevation of the gene causes interferon resistance that in turn causes insulin resistance in the liver. Depletion of this gene has been made possible by pioglitazone which results in the reduced insulin resistance in the liver although it may cause systemic insulin resistance (Schatz, 2000). The suppression of gene SOCS3 by pioglitazone gives it the antiglycemic and ant diabetic property hence it has bee used in the management of the two cases. References Thomas, M. (2013).  Understanding type 2 diabetes: Fewer highs fewer lows better health. Wollombi, N.S.W: Exisle Publishing. Feinglos, M. N., & Bethel, M. A. (2008).  Type 2 diabetes mellitus: An evidence-based approach to practical management. Totowa, NJ: Humana Press. Schatz, H. (2000).  Pioglitazone: From discovery to clinical practice. Heidelberg: Barth Source document

Linear Model of Communication Essay

It is a one way model to communicate with others. It consists of the sender encoding a message and channeling it to the receiver in the presence of noise. Draw backs – the linear model assumes that there is a clear cut beginning and end to communication. It also displays no feedback from the receiver. †¢ For example; a letter, email, text message, lecture. There are two main linear model which are used to explain the human communication process. They are †¦ †¦ †¦ †¢ Shannon and Weaver Model (1949) The original model was designed to mirror the functioning of radio and telephone technologies. Their initial model consisted of three primary parts: sender, channel, and receiver. The sender was the part of a telephone a person spoke into, the channel was the telephone itself, and the receiver was the part of the phone where one could hear the other person. Shannon and Weaver also recognized that often there is static that interferes with one listening to a telephone conversation, which they deemed noise. The noise could also mean the absence of signal. †¢ Berlo’s SMCR Model (1960) In 1960, David Berlo expanded on Shannon and Weaver’s linear model of communication and created the SMCR Model of Communication. The Sender-Message-Channel-Receiver Model of communication separated the model into clear parts and has been expanded upon by other scholars. Shannon – Weaver Model Claude Elwood Shannon (April 30, 1916- February 24,2001) was an American mathematician, electronic engineer and cryptographer.He is known as â€Å"the father of information theory†. He was a student of Michigan University. He was a graduate in both engineering and mathematics. He worked in Bell laboratories, Massachusetts Institute of Technology, Institute for Advanced Studies.He got IEEE Medal of Honor, Kyoto Prize, Harvey Prize awards. [pic] Warren Weaver (July 17, 1894- Nov 24, 1978) was an American Scientist, Mathematician and Science administrator.He is widely recognized as one of the pioneers of machine translator and as important figure in creating support for science in US. He was a student of University of Wisconsin- Madison. Introduction: Shannon- Weaver model is mother of all model in communication. The theory based on how a concept goes to a place from another. It is also known as mathematical theory of communication. Shannon published â€Å"A Mathematical Theory of Communication† article in two parts in the July and October numbers of the â€Å"Bell System Technical Journal† in 1949. The book co-authored with Weaver â€Å"The Mathematical Theory of Communication† reprints Shannon’s article. Later Weaver explained the model and popularized it. Formula: C = W log2(1+S/N) where, C – Channel capacity W – Bandwith S – Signal level N – Noise power This model is specially designed to develop the effective communication between sender and receiver. Also they find factors which affecting the communication process called â€Å"Noise†. At first the model was developed to improve the Technical communication. Later it’s widely applied in the field of Communication. Communication model: The process of Shannon- Weaver model is as below †¦ †¦ †¦ [pic]Some key points of this model are given below †¦ †¦ †¦ †¢ Information source chooses desired message among a set of possible messages which can be mixture of any form of written or spoken, image or sound. †¢ Transmitter changes the message into the signal, also known as encoder. †¢ Message is the thing which is sent and received and all communication is about. †¢ Channel is the path that message passes through from the transmitter to the receiver. †¢ Receiver is the reverse transmitter which changes the signal back into the message, also known as decoder. †¢ Destination is the target place of the transmitted message. †¢ Noise is any unwanted additions to the transmitted signal which cause distortion or error in transmission. [pic] Shannon Weaver model of communication Requirments: There are eight (08) requirments of Shannon- Weaver model. They are †¦ †¦ †¦ †¢ Source †¢ Encoder †¢ Message †¢ Channel †¢ Decoder †¢ Reciever †¢ Noise †¢ Feedback Example: Mr. Khan made call to his assistant â€Å"come here I want to see you†. During his call, noise appeared (transmission error) and his assistant received â€Å"I want† only. Again Assistant asked Thomson (feedback) â€Å"what do you want Mr. Khan?†. Sender : Mr. Khan Encoder : Telephone (Mr. Khan) Channel : Cable Noise : Distraction in voice Reception : Telephone (Assistant) Receiver : Assistant. Due to transmission error or noise, Assistant can’t able to understand Thomson’s messages. Criticism: There are also criticism of Shannon- Weaver model. †¢ One of the simplest model and its general applied in various communication theories. †¢ The model which attracts both academics of Human communication and Information theorist to leads their further research in communication. †¢ It’s more effective in person-to-person communication than group or mass audience. †¢ The model based on â€Å"Sender and Receiver†. Here sender plays the primary role and receiver plays the secondary role (receive the information or passive). †¢ Communication is not a one way process. If it’s behaved like that, it will lose its strength. For example: Audience or receiver who listening a radio, reading the books or watching television is a one way communication because absence of feedback. †¢ Understanding Noise will helps to solve the various problems in communication. Conclusion: Basically Shannon made this model not for the human communication. Rather he conceived the mediated communication, to be explicit the very phony conversation. Later human communication scholars began to use it to explain the unmediated human communication, as it is very simple and not far away. Berlo’s SMCR Model [pic] Dr. David K. Berlo (1929- 1996) was an American communication experts. He is called as â€Å"the father of modern mass communication†. Dr. Berlo explained his model as an expansion of Shannon- Weaver model in 1960 in his book â€Å"The Process of Communication†. He was a professor of department of communication, Michigan State University (MSU). Introduction: The model of David Berlo is known as â€Å"Berlo’s SMCR model†. The meaning of SMCR is †¦ †¦ †¦ Source Message Channel Reciever Communication Model: [pic] Elements of communication S – Source The source in other words also called the sender is the one from whom the thought originates. He is the one who transfers the information to the receiver after carefully putting his thoughts into words. It is done with the help of †¦ †¦ †¦ ââ€" ª Communication Skills ââ€" ª Attitude ââ€" ª Knowledge ââ€" ª Social System ââ€" ª Culture M – Message When an individual converts his thoughts into words, a message is created. The process is also called as Encoding. Any message further comprises of the following elements: ââ€" ª Content ââ€" ª Element ââ€" ª Treatment ââ€" ª Structure ââ€" ª Code C – Channel Channel actually refers to the medium how the information flows from the sender to the receiver. Some are †¦ †¦ †¦ †¢ Hearing. †¢ Tasting. †¢ Seeing. †¢ Smelling. †¢ Touching. All the five senses are the channels which help human beings to communicate with each other. R – Receiver When the message reaches the receiver, he tries to understand what the listener actually wants to convey and then responds accordingly. This is also called as decoding. The receiver should be on the same platform as the speaker for smooth flow of information and better understanding of the message. He should possess good communication skills to understand what the speaker is trying to convey. He should have the right attitude to understand the message in a positive way. His knowledge should also be at par with the listener and must know about the subject. He should also be from the same social and cultural background just like the speaker. [pic] Example of SMCR model Weak Point: †¢ No feedback †¢ More unilinear Strong Point: †¢ Save money †¢ Save time †¢ Easy to pass †¢ Repeatation †¢ Replication Conclusion: Though there is no feedback but Berlo’s SMCR model has a in development communication.

Innovative Product

Introduction Nowadays, innovative is an essential advantage in this dog-eat-dog market for every organization. Innovative can be everything that is new and not exist in current market, however in order to fulfill the gap in this demanding market, organizations must be very innovative to come out with new products and services. Organizations nowadays are recruiting employees who are creative and innovative because they are person who have sensitive antenna to sense and observe what the people want and need.In current market, thermos water bottle is very common for people to store their drinks; because thermos water bottle allows people to keep their drinks cold or warm for a very short period of time. Therefore, there would be a gap exists where the people want to drink cold or hot beverage at anytime and anywhere they want. To fulfill this gap, DualBottle has came out as it is a thermos water bottle which has the function of heating and freezing the beverage inside the thermos water bottle at anytime the customer wants.In other words, DualBottle will act like a refrigerator to chill the water as cold as it can or heating up the water just like a water boiler. In the current market, there is no similar product that has the function like DualBottle and this innovative product will bring in another level of convenience to the consumers in the market. Hence, people may want this new product to be in the market. In fact, water bottle in the current market is only used for storing water and sometimes not even suitable to store hot water as some water bottles have no qualified certificate because it is made of lower quality of plastic.In addition, DualBottle enables people to get hot or cold water easily in their daily activities. In this assignment, we are going to discuss in-depth on market research of DualBottle and also new product descriptions and specifications. Market Research Direct competitors There are several direct competitors for DualBottle which they hav e the similar types of product in the same market such as heaters, coolers and normal water bottles. In this case, keeping on track on consequential technological innovations is very important for a particular company to maintain a competitive advantage in the market.Firstly, the innovative product will have certain competition and comparatives with those existing and well-known brand like Thermos, Zebra, Camelback, Klean Kanteen, SIGG, Cheeki, Eco vessel and many more. These brands are the direct competitors for the DualBottle because these brands produce quality stainless steel and aluminium water bottles similar to the DualBottle but of course every brand has its specialty of their own products such as the designs, different attractive colors, functions, specifications, future and its outlook.These brands are the main direct competitors for DualBottle because both these products from these brands have the similar functions of heat preservation and have these brands are historical as compared with the new product. Though our new innovative product, DualBottle can reheat and re-chill the drinks; however, the existing of the products can only help to maintain the heat and the warmness of the drinks. In fact, people may be more likely to choose old brand due to brand loyalty and influenced by the power of word of mouth.The brand new product might be very novel yet it is still under the observation period to attract and being recognized by the people. On the other hand, old products are more creditable and always have good comments from one consumer to another consumer. Indirect competitors Beside those direct competitors, there are a number of indirect competitors for the DualBottle. Indirect competitors are the competitors that compete with the DualBottle indirectly. For example refrigerators that can cool the water, this is an indirect competitor because households have refrigerators at home.So it is considered as an indirect competitor. On the other hand, th e kettle and hot water flask are also indirect competitors to the DualBottle because at home people use kettle to boil water and hot water flask because the flask is to keep the hot water to remain hot. Other than that, Mineral waters that are sold in sundry shops, supermarkets, convenient shops, and other places are considered as indirect competitors because they have cold beverages and warm beverages separately. Instead of purchasing DualBottle, customers might just purchase mineral waters for daily usage.Besides that, water dispensers are the main indirect competitors because the DualBottle mostly targeted customers are people who work in office, travel daily and also students. Water dispensers are available in all colleges and offices. Hence, instead bringing the water bottles along with them, customers may prefer using the water dispenser for cold and warm drinks. So it is considered a main competitor to the DualBottle that competes in the market. Furthermore, companies such as Starbucks also are served as the indirect competitor for the new product.Although Starbucks specialized on producing good and tasty coffee, the company itself has launched their own tumbler which also has the similar function with this new product as tumbler can be used to fill up the hot beverages. Besides that, Starbucks also has a promotion for its own customers by using the tumbler when they purchase hot beverage. They can get the RM2 rebate by using the tumbler. Hence, most of the customers who loyal and fascinating in Starbucks will tend to purchase the tumbler to get better offer. This phenomenon also will be one of the issues for the launching of new product.Next, in terms of the future competition for the DualBottle where in this new era technology is growing in a fast pace, all the products that selling in the market already be advanced. In the past years, these products are not in existence. However, in today’s fast development society, these products cannot be le ft out and more innovative and modern products are being launched. Most of the young adults have strong interest in trying new products. When this situation happened, all of the past products might be left out.Thus, to consolidate the base of new product in the competitive market, branding should be taken into consideration. Future competitors not only on the products themselves, but also included the consumer behaviour in today’s society. There will be always new competitors that will enter the market because of the advance of the technology. Target customers The innovative product, water bottle thermos is designed to satisfy all the needs of the individual and company. Furthermore, targeted customers are normal people who travel a lot; they can keep warm or cold water together with them while travelling in the car or bus.For instance, long distance travellers can keep hot coffee in the DualBottle so they can drink it while travelling to keep them fresh. Besides that, we are also targeting DualBottle on working adults and students who usually face with busy and tight schedule where they may be even unable to have their proper meals. For example, an event executive, Amanda is too busy with her task and could not even find time to have her meals and so, with this DualBottle, she is now able to enjoy her favourite drinks either in hot or cold at anytime and anywhere even when she is busy.With our unique selling point of DualBottle, that is the ability to reheat and re-freeze the drinks quickly by using the steel casing in which making DualBottle appeared to be so practical; it may also attract many companies to purchase our product as it can provide a high level of convenience to their employees. Therefore, we may be indulging ourselves in both B2B and B2C market in order to gain higher market share respectively and establishing a strong position in the market. We strongly believe that targeting the right consumers will achieve a desirable benefit to our innovative product, DualBottle.New Product First of all, stainless steel water bottle maybe very common in this current market such as Thermos, Klean Kanteen, Thinksport, and Eco Vessel. In fact that, there are just normal insulated water bottles which can keep drinks cold or hot for a short period however; DualBottle is coming up with an innovative idea where the water bottle is chargeable in order to heat up the drinks or make the drinks chilled. Although it appears to be nothing different from ordinary bottle, DualBottle has a ‘magic' function that cannot be found in the current market.The uniqueness that able to chill soft drinks or to retain temperature of warm Chinese tea with a tiny â€Å"plug and play† kind of component attached to make DualBottle more standout. Similarly to some other portable coolers, it uses thermoelectric cooling system concept to switch between two modes (cold and hot) with just a button. In line with technology advancement, DualBottle is d esigned with an external component that can be attached from the bottom of the bottle and it is contacted with a metal plate to serve as conductor in order to transmit cold and heat.Meanwhile, instead of operating in 12 or 24 volts direct current (DC) which is similar to mini fridge, we would replace the battery storage with a 2800 milli-Ampere-hour (mAh) rechargeable battery. For instance, two hours are required to get the battery fully charged and it could be used for ten consecutive hours. Besides, there would be two different ways to charge the battery component by using direct current (DC) and alternating current (AC). It would be more convenient as users do not need to plug-on direct current or alternating current in order to use of the function because there would be power reserved in battery component.Additionally, DualBottle will have an automatic power switch off when the water temperature is heated up to 70 °C and the water temperature is chilled down to 3 °C to 5 ° C. On the other hand, DualBottle can be presented more innovative by introducing another range of models that uses solar energy as an optional charging method therefore; the battery can be charged automatically whenever solar heat is stored. Moreover, when users do not feel like using the function, they could always remove the external component to function it as ordinary bottles like Bros, Sigg and Zebra.In addition, DualBottle is chargeable by using USB port charger and car power adapter as well, this idea enables users to charge DualBottle whenever they want. In fact, DualBottle can act more than a common water bottle where it can perform as a water warmer to keep the beverage warm for 4-6 hours because of the double-wall insulation designed; then it also can act as a water heater to heat up the beverage up to 70 °C, lastly it perform as a water cooler to hill the beverage down to 3 °C. Forget about the traditional design of Thermos bottle in which it looked heavy with stainl ess steel silver colour; DualBottle would design the products with relatively new colours and standout themes. DualBottle would look more colorful and attractive by adding some printings on it, the designs can be plain but sharp colors and candy colours, animal prints for fancy female group, and users can even print their pictures or words on DualBottle.To target different types of customers, DualBottle would allow customers to choose their favourite colour and design or to custom-made their bottle by choosing what design, features, function, colour, and engrave their name on the bottle. Besides, it would be designed for easy to carry by attaching a strap and also slim fit exterior outlook of the bottle. Meanwhile, the cover cap of DualBottle would be anti-leaking water designed which are made by rubber and plastic. It would be easier to design the bottle with open-close cover, instead of using rubber grip cap cover.However, there are also pros and cons to adopt the design of open-c lose cover. For instance, rubber grip cap cover can have better prevention of losing the water temperature in the bottle as compared with the open-close cover. As people are more health conscious nowadays, DualBottle uses stainless steel, aluminium and bisphenol A (BPA) free as inner bottle materials in production line hence; it would not be harmful to the users. Since a metal plate would acts as an electrical conductor to heat up or chill cold the drinks; stainless steel, aluminium and BPA free plastic materials are not an issue to end-users.In general, DualBottle has three different kinds of bottles but they perform the same function for users. This is because to target different group of customers as stainless steel material is usually expensive, aluminium material is on the average price, and plastic material would be cheaper. Nevertheless, high quality of stainless steel materials are usually weigh heavier as compared to aluminium and plastic materials; so materials made of Dua lBottle might be affect the weight of product but however, DualBottle has only two standardized bottle volume which are 500ml and 750ml.To be a part of contributing towards environmental friendly program, we would to use recycle materials if possible. The quality of the product must be proven through some international recognized authorities like FDA (US Food & Drug Administration), LFGB (Europe Food Contact Material Standard), ISO (International Organization for Standardization), and SIRIM (Standard and Industrial Research Institute of Malaysia).Besides, DualBottle would only use high quality of electric thermos which it is also often used by Thermos, Klean Kanteen, and La Gourmet; this is to ensure that DualBottle can produce high quality products instead of using cheap materials. With the fact that the production cost might not be cheap and therefore it is expected that DualBottle is placed in high quality and high price position. Conclusion In the current market, thermos water b ottle is frequently used by the people to store their drinks and keeping their drinks cold or warm for only a very short period of time.Our group has established the gap within the market where people may want to enjoy cold or hot drinks at the anytime and anywhere in their daily life. Thus, we have come out with an innovative product called â€Å"DualBottle†. In developing DualBottle, it is apparent that we will be facing those direct competitors like Thermos, Klean Kanteen, Sigg, and Zebra which have dominated the market for quite a long time in producing thermos water bottle. However, these products only consists the function of preserving heat and not heating or freezing like what DualBottle can do.On the other hand, we also will be facing some of the indirect competitors in the market like water dispenser companies, mineral water companies, some electrical companies that produces kettle and water boiler and even Starbucks as they had launched their own brand tumbler to i ncrease loyalty of their customers. The DualBottle is targeted at travellers, students and working adults who may be very eventful and does not even have the time to sit down and enjoy their drinks. Thus, the ability of DualBottle to heat and freeze drinks enable these people to have a moment of pleasure on their favourite drinks either in hot or cold.The practical side of DualBottle may attract companies to buy in bulk from us in order to supply to their employees as it is very convenient to their daily activities. DualBottle introduces a function where it can be heated up the beverage or chilled the beverage in water bottle by only clicking a button. This function can be done by attaching a metal plate which acts as conductor on the bottom of the inner bottle and then an external component to act as battery to transmit energy.In additional, the external battery is actually an external component which can be attached or removed from the bottle. It is easy to charge by using adapter , USB port, car power adapter, and also solar energy. Moreover, Dualbottle design the bottle by using 3 different kinds of materials which include stainless steel, aluminium, and plastic. There are all having the same performance and with 2 standardized capacity volume of bottle which are 500ml and 750ml.DualBottle may obtain international certificates by government organizations to prove that the bottles are safe to use and has no harms to health. Besides, it would be having attractive outlook as the designs are standout and DualBottle enables customers to custom-made their bottle as well. The cover cap of bottle may be open-close cover design because of convenience and anti-leaking purpose. In conclusion, DualBottle is a high quality dual-function bottle and hence, it would be also selling at higher price. Reference list Alicia,2009.Top 5 Stainless Steel Water Bottles. [online] Available at: [Accessed on 2nd April 2012] Better Bottle Stainless, 2012. [online] Available at: [Access ed on 3rd April 2012] Hydro Flask, 2012. [online] Available at: [Accessed on 3rd April 2012] Klean Kanteen, 2012. [online] Available at: [Accessed on 4th April 2012] Shop Naturally, 2012. [online] Available at: [Accessed on 4th April 2012] SIGG Design Bottles, 2012. [online] Available at: [Accessed on 3rd April 2012] Zazzle water bottles, 2012. [online] Available at: [Accessed on 4th april 2012]

Interpretation and Significance of Lao Tzu's Sayings Essay

Interpretation and Significance of Lao Tzu's Sayings - Essay Example Taoists have developed their principles through the processes of self- realization and self-invention based on a variety of philosophical and environmental contexts. Like other organized religion, Daoism has its own doctrines or scriptures for its followers. In their collaborate effort Yijie Tang, and TÊ »ang I-chieh have rightly put it: â€Å"The early form of Daoism (Taoism) held that its body of belief was made up of the tenet of â€Å"the ascent of the three in one â€Å"that is,† the unity of heaven, earth, and man for the attainment of the Great Peace; the blending of the essence, breath and shen to become a saint.† (Yijie Tang, and TÊ »ang I-chieh, 1991, 76 pp.). Daoism (Taoism) is familiar to the world through the famous books Chuang-Tzu and Tao Te Ching. Daoist sayings are more comprehensive, filled with metaphysical principles and these principles emphasis a formation of ‘oneness’ that follow the complex form of diverse world. The book had wide ly accepted as the great sayings of Lao Tzu. It has considered as the unique ideology in Chinese history. Lao Tzu explores his ideas through the help of rhyme and rhythm, paradox, analogy, and proportion. In his masterpiece Lao-Tzu remarks, every people have his/her own freewill and desires. The Chinese word Tao/ Dao means the way to the universe. When analyzing these sayings, one can understand that it is difficult to define these sayings appropriately. In the first part of this work, the author tries to give the foundation about the ideology Tao Te Ching. When analyzing the plight of modern man one can easily find that the sayings of Lao-Tzu have enough relevance. The temporariness of material things and pleasures have well expressed in the sayings of Lao Tzu. The followers of Lao-Tzu purport that the ultimate aim of life is to gain the ‘Great Peace’. One cannot attribute it a clear form or structure that it may appear in any name or material existence.

Statistical Analysis of Experimental Data Research Paper

Statistical Analysis of Experimental Data - Research Paper Example Analysis of variance (t-tests) can be used to estimate the probability that the underlying phenomena are not the same (Sergey, &Valery, 2012). Research plays a major role in psychology. The results are relayed through statistics. In order to understand how people behave, think and feel, Psychologists depend on research. Research needs to be organized to be understood by psychologists; therefore statistics help organize the information and make the connection between the research and group of people for easier understanding. These professionals use statistical methods to help them make sense of the numbers they collect when conducting research (James, Glen, Robert, Reid, 1998) Psychology and other human sciences employ statistics in helping understand and in the process solve various issues. A common example can be seen with psychologists’ keen interest on how health is affected by stress. A focused question might involve the study of a specific psychological symptom and its im pact on the health of the population. To assess whether the symptom is a good indicator of stress we need to measure the symptom and stress levels in a sample of individuals from the population. It is not immediately clear how we should go about collecting this sample, i.e. how we should design the study (Mandel, 2012). The data sets that psychologists collect will usually consist of one more observations on one or more variables. A common example can be seen with psychologists’ keen interest.

How is the idea of architecture being conveyed and what, finally, does Essay

How is the idea of architecture being conveyed and what, finally, does this building mean - Essay Example In that case we do using the visual perception of the building (Tomaszewski, 2003). Therefore architecture relates to the entire design of the building which in the end gives the unique visual impression that we can see. Further, the buildings architectural designs can also communicate their history, iconography, or perhaps the people who built them. Different emotions or feeling as well can be communicated by different architectural connotations. Amongst the above connotations, also context, flexibility, formality, function and simplicity are some of the aspects that can be utilized by architects to communicate through the building design. This implies that architecture is thus a form of language. Architecture is a symbolical representation of language through which different emotions or information can be communicated (Tomaszewski, 2003). Therefore, buildings can be read just like texts. This essay discusses how the idea of architecture is being conveyed using Kolumba Museum buildi ng. Additionally, the essay also discusses what is finally meant by the Kolumba Museum building. Kolumba Museum is an art museum located in cologne Germany. The Museum has a monumental building designed by Peter Zumthor. This site was formerly, St. Columbia Church run by the diocese of Cologne. The museum is one of the oldest founded by the society for Christian art back in1953. The new home was designed by peter Zumthor in 2003. The site where this building sits was formerly occupied by the St Columbia church but was later to be destroyed during the World War II. The structure designed by Zumthor shares a site with the ruins of St. Columbia’s gothic church. The building is wrapped up with a perforated brick faà §ade including the entire museum (Zumthor, 2008). The building additionally has 16 exhibition rooms with varying qualities depending on the day light allowed in. with a light gray wall made of

Role of Transaction Cost in Intermediation Process Assignment

Role of Transaction Cost in Intermediation Process - Assignment Example For instance, when the bank acts as intermediary it connects individuals with different needs, financial inputs at different point of time. It allows people to save money into various accounts like savings account, time deposits, salary account, pension funds, and so on. After the bank accepts deposits from an individual it invests that sum into projects which have returns greater than or equal to the cost of investment which is also the bank’s liability. Now, if any corporate or individual approaches the bank for loan, the bank will charge interest on that loan. This interest will increase the transaction cost of the individual or corporate. The interest charged on loans by the bank on the borrower will obviously higher than what the bank has to pay to the depositors. This is because in order to operate in the market and serve the community it has to maintain a profit margin for all transaction which otherwise would lead to collapse of business. The advantage that an individu al or a corporate will get from an intermediation process is that the credit risk is transferred from individual borrower to the bank. This is because when a corporate raises funds from market directly without any intermediation, the credit risk of parties to transaction has to be evaluated personally. This is true in case of over-the-counter markets where the contracts are much customised according to individual requirements and parties to contract enter into agreement with each other without any intermediary. This reduces their transaction cost but also increases the credit risk. When an intermediary is introduced in the same model as in case of exchange traded funds, the transaction cost increases due to brokerage charges, maintenance fee, printing and advertising charges, commissions, and so on. The various costs are passed on to the fund raiser and hence decreasing the transaction cost of the individual from intermediation process (Buckle and Thompson, 2004, p.37). From the abo ve discussion, the role of transaction cost in the intermediation can be summarised as follows. The intermediation process aims to connect the individuals with surplus funds with individuals with deficit funds in order to channel funds properly in the economic system. In the process of intermediation the individuals and corporate is able to reduce search cost of raising funds, verification cost, monitoring cost, and credit worthiness of the parties involved in transaction. Since the intermediary provides these services, it charges a fee or commission for providing these services which increases the cost of transaction from intermediation process but such cost is much less compared to the benefit from intermediations (Mishkin and Eakins, 1998, p.369). For instance, the banks offer standardised services and products that reduce cost of transaction and the risk of investment. The OTC market mainly operates without intermediation and is hence a much more risky option. Role of Asymmetric Information in Intermediation Process In order to understand the role of asymmetric information in the intermediation process, it is important to understand the concept of asymmetric information. Asymmetric information arises from a situation when one party to transaction has more information compared to the other. This is generally

ABSENTEEISM WITHIN THE WORK PLACE Essay Example | Topics and Well Written Essays - 5750 words

ABSENTEEISM WITHIN THE WORK PLACE - Essay Example The paper tells that thÐ µ pÐ µriÐ ¾d mÐ µntiÐ ¾ns tÐ ¾ thÐ µ nÐ ¾nÐ °ttÐ µndÐ °ncÐ µ frÐ ¾m nÐ ¾nÐ °ttÐ µndÐ °ncÐ µ frÐ ¾m wÐ ¾rk. This is Ð ¾nÐ µ Ð ¾f thÐ µ fÐ ¾rÐ µmÐ ¾st difficultiÐ µs fÐ °cÐ µd by businÐ µssÐ µs rÐ ¾und thÐ µ wÐ ¾rld tÐ ¾dÐ °y. UnschÐ µdulÐ µd Ð °bsÐ µntÐ µÃ µism hÐ °rshly injurÐ µ thrÐ ¾ughÐ ¾ut thÐ µ Ð °ssÐ ¾ciÐ °tiÐ ¾n Ð °s Ð ° Ð ¾utcÐ ¾mÐ µ Ð ¾f dÐ µcrÐ µÃ °sÐ µ Ð ¾f prÐ ¾ductivity, highÐ µr chÐ °rgÐ µs Ð ¾f chÐ °rtÐ µring Ð °ddÐ µd Ð µmplÐ ¾yÐ µÃ µs Ð °nd rÐ µducÐ µd mÐ ¾rÐ °lÐ µ Ð °midst wÐ ¾rkÐ µrs. It is timÐ µ thÐ °t Ð µmplÐ ¾yÐ µrs Ð °ddrÐ µss this difficulty Ð ¾n Ð ° mÐ °in cÐ ¾ncÐ µrn bÐ °sis. It is chÐ °rÐ °ctÐ µrisÐ µd Ð °s Ð °ny mÐ °lfunctiÐ ¾n Ð ¾f thÐ µ wÐ ¾rkÐ µr tÐ ¾ rÐ µpÐ ¾rt fÐ ¾r Ð ¾r stÐ °y Ð °t wÐ ¾rk Ð °s Ð °rrÐ °ngÐ µd, dÐ µspitÐ µ Ð ¾f thÐ µ cÐ °usÐ µ. ЕmplÐ ¾yÐ µÃ µs mÐ °y bÐ µ missing fÐ ¾r divÐ µrsÐ µ cÐ °usÐ µs, Ð µncÐ ¾mpÐ °ssing sicknÐ µss, lÐ µthÐ °rgic mind-sÐ µt, fÐ °mily crisÐ µs, tÐ ¾Ã ¾ much fÐ ¾rcÐ µ Ð °nd tÐ µnsiÐ ¾n, mÐ ¾nÐ ¾tÐ ¾nÐ ¾us wÐ ¾rk, Ð ¾r gÐ µnÐ µrÐ °l dissÐ °tisfÐ °ctiÐ ¾n with thÐ µ wÐ ¾rk. SÐ °lÐ µs Ð µxpÐ µrt Ð µxtrÐ °cts fÐ ¾r Ð ¾thÐ µr cÐ °usÐ µs, Ð °s in thÐ µ wÐ ¾rkplÐ °cÐ µ principlÐ µ, lÐ ¾ng cÐ ¾mmutÐ µ, Ð ° strugglÐ µd cÐ ¾nnÐ µctiÐ ¾n with thÐ µ supÐ µrvisÐ ¾r Ð °nd thÐ µ nÐ µÃ µd Ð ¾f Ð °ffiliÐ °tiÐ ¾n Ð °s Ð ° cÐ °usÐ µ fÐ ¾r nÐ ¾nÐ °ttÐ µndÐ °ncÐ µ frÐ ¾m wÐ ¾rk. WhÐ °tÐ µvÐ µr thÐ µ cÐ °usÐ µ fÐ ¾r Ð °bsÐ µntÐ µÃ µism is nÐ ¾t Ð ° whÐ ¾lÐ µsÐ ¾mÐ µ pÐ µrfÐ ¾rm Ð °nd shÐ ¾uld tÐ °kÐ µ stÐ µps tÐ ¾ Ð ¾rgÐ °nisÐ µ thÐ µm cÐ ¾mpÐ µtÐ µntly. InnÐ ¾cÐ µnt Ð °bsÐ µntÐ µÃ µism mÐ µntiÐ ¾ns tÐ ¾ thÐ µ cÐ ¾rrÐ µspÐ ¾ndÐ µncÐ µ fÐ ¾r thÐ µ idÐ µnticÐ °l cÐ °usÐ µs thÐ °t Ð °rÐ µ Ð °ftÐ µr thÐ µ cÐ ¾mmÐ °nd Ð ¾f Ð µmplÐ ¾yÐ µÃ µs, Ð °s misfÐ ¾rtunÐ µs Ð ¾r illnÐ µssÐ µs. In such Ð °ttÐ µnuÐ °ting cÐ ¾mpÐ ¾nÐ µnts Ð µmplÐ ¾yÐ µÃ µs shÐ ¾uld nÐ ¾t bÐ µ prÐ ¾sÐ µcutÐ µd fÐ ¾r dÐ µnying tÐ ¾ prÐ ¾cÐ µÃ µd tÐ ¾ wÐ ¾rk. ThÐ ¾sÐ µ tÐ ¾ blÐ °mÐ µ Ð °bsÐ µntÐ µÃ µism, Ð ¾n thÐ µ Ð ¾thÐ µr hÐ °nd, whÐ µn Ð µmplÐ ¾yÐ µÃ µs missing Ð °t thÐ µ timÐ µ whÐ µn thÐ µy Ð °rÐ µ flÐ °wlÐ µssly Ð °dÐ µpt tÐ ¾ jÐ ¾in Ð ¾fficÐ µ. This kind Ð ¾f nÐ ¾-shÐ ¾ws Ð °rÐ µ hÐ °bituÐ °lly shÐ ¾ckÐ µd fÐ ¾r him cÐ °n bÐ µ Ð ° prÐ ¾blÐ µm fÐ ¾r thÐ µ Ð °ssÐ ¾ciÐ °tiÐ ¾n in thÐ µ lÐ ¾ng run

Write up Essay Example | Topics and Well Written Essays - 500 words - 1

Write up - Essay Example fasalt and marble schiet which according to Erickson were formed through heat and pressure that made them to melt miles below the sea level (Erickson 59). The rain energy played a leading role in transporting these grains. The age of this fountain formation is 300 million years and its height is approximately 10000 feet high. At the Morrinson, there were the lyons and lykins formations that were formed about 251 million years ago. With respect to color the formations comprise of green, gray and maroon clay stone as well as mudstone. This formation was necessitated by movement and deposition of grains. There is also the presence of fossil deposits including dinosaur bones. This is exemplified by their wavy layers of muddy limestone that is indicative of stromatolites. The movement of the grains is attributed to rain energy that is also responsible for the weathering process. Their size according to Erickson is 400 feet thick (Erickson 59). With respect to the period of formation, it is a bit difficult to tell because this is largely depended on the kind of sediment carried in suspension as well as how well this is deposited. A walk through the Dakota formation offered useful insights regarding sandstone formation. In this, there was a continuity of various sandstone beds located at distinct spots along the road. Also, there were different sedimentary structures. These variations in the layers imply that the process of formation is continuous and not static. Notably, each layer was formed during a specific period with the bottommost layer having been formed earlier than the topmost layer. This shows that the process of deposition is continuous and being experienced even today. This is because the rain energy that necessitated previous depositions is still being experienced in the region. This structure also offers useful information about the deposition rate experienced in distinctive years. Notably, the layers differ considerably in size. This shows that the

Solutions to Stress Essay Example | Topics and Well Written Essays - 750 words

Solutions to Stress - Essay Example Some people develop socio-psychological problems, resulting in low confidence and low adjustment within the given paradigm. Thus, ‘stress’ is the emotional instability in the face of adverse situations. Stress can be broadly defined as ‘the adverse reaction people have to excessive pressures or other types of demand placed upon them’ (HSE, 2001). The more contemporary and scientifically accepted definition recognizes stress as the ‘perceived pressure that exceeds one’s ability to cope’ within the pre-defined socio-psychological parameters (Palmer, Cooper & Thomas, 2006). The cognitive reality of stress has different level of adjustment and therefore, stress level of every person is different. Stress is often perceived as an act of defense against an imagined or actual injustice or threat or it may be an expression of frustration for one’s own inability to face certain situations of life in a manner that would effectively alleviate pain. The diversity of reasons may be attributed to stress that may result in harming others or oneself because a person loses his ability of objectivity and rationale when he or she is under stress. Hence, stress is not good for our welfare and needs to be rationalized to find its root cause and thereby find best measures to control it. The psychological well being is important part of healthy life. Life is not a smooth road and the various obstacles in one’s life may or may not become countless reasons for people to have emotional stress. The traumatic events, the unexpected changes in our personal and professional life or even small things that may not be to our liking may constitute reasons for stress. Insecurities in life may also become key factors for stress. Sometimes, the reason cannot be attributed to one single entity but may be a result of accumulated events or adverse situations that could have reached the limit of